{"id":33213,"date":"2026-02-06T08:48:25","date_gmt":"2026-02-06T07:48:25","guid":{"rendered":"https:\/\/educationalevidence.com\/?p=33213"},"modified":"2026-02-09T09:58:15","modified_gmt":"2026-02-09T08:58:15","slug":"gracies-barbacid","status":"publish","type":"post","link":"https:\/\/educationalevidence.com\/ca\/gracies-barbacid\/","title":{"rendered":"Gr\u00e0cies, Barbacid"},"content":{"rendered":"<p>Mariano Barbacid en el C\u00edrculo de Bellas Artes, 2025. \/ Imatge: Wikipedia &#8211; Autor: <span style=\"color: #0000ff;\"><a class=\"new\" style=\"color: #0000ff;\" title=\"User:MAT.MHACCV (page does not exist)\" href=\"https:\/\/commons.wikimedia.org\/w\/index.php?title=User:MAT.MHACCV&amp;action=edit&amp;redlink=1\" target=\"_blank\" rel=\"noopener\">MAT.MHACCV<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a style=\"display: inline-block;\" href=\"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/deed.ca\" target=\"_blank\" rel=\"license noopener noreferrer\">Llic\u00e8ncia Creative Commons<img decoding=\"async\" style=\"height: 22px!important; margin-left: 3px; vertical-align: text-bottom;\" src=\"https:\/\/mirrors.creativecommons.org\/presskit\/icons\/cc.svg?ref=chooser-v1\" \/><img decoding=\"async\" style=\"height: 22px!important; margin-left: 3px; vertical-align: text-bottom;\" src=\"https:\/\/mirrors.creativecommons.org\/presskit\/icons\/by.svg?ref=chooser-v1\" \/><img decoding=\"async\" style=\"height: 22px!important; margin-left: 3px; vertical-align: text-bottom;\" src=\"https:\/\/mirrors.creativecommons.org\/presskit\/icons\/nc.svg?ref=chooser-v1\" \/><img decoding=\"async\" style=\"height: 22px!important; margin-left: 3px; vertical-align: text-bottom;\" src=\"https:\/\/mirrors.creativecommons.org\/presskit\/icons\/nd.svg?ref=chooser-v1\" \/><\/a><\/p>\n<p><strong><img decoding=\"async\" class=\"alignleft wp-image-15012\" src=\"https:\/\/educationalevidence.com\/wp-content\/uploads\/2024\/04\/Therfer-web-color-150x150.jpg\" alt=\"\" width=\"70\" height=\"70\" \/><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/twitter.com\/therfer\" target=\"_blank\" rel=\"noopener\"><strong>Antoni Hern\u00e1ndez-Fern\u00e1ndez<\/strong><\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>El 2008 la meva mare va morir de c\u00e0ncer de p\u00e0ncrees. Se la va endur en pocs mesos. Encara que, per descomptat, la bestiola feia m\u00e9s temps que estava dins, sense avisar. El c\u00e0ncer de p\u00e0ncrees, en particular <strong>l&#8217;adenocarcinoma ductal pancre\u00e0tic (PDAC),<\/strong> continua sent des de llavors una de les neopl\u00e0sies m\u00e9s letals. La seva resist\u00e8ncia a les ter\u00e0pies convencionals i el diagn\u00f2stic tard\u00e0 han convertit aquesta malaltia en un paradigma del <strong>frac\u00e0s terap\u00e8utic en oncologia<\/strong>. En aquest context, l&#8217;estudi liderat per <strong>Mariano Barbacid<\/strong> al <em>Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO)<\/em>, publicat recentment a <a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2523039122\"><em>Proceedings of the National Academy of Sciences (Liaki et al., 2025)<\/em><\/a>, constitueix una fita experimental rellevant, malgrat que encara sigui estrictament precl\u00ednica. I resulta esperan\u00e7ador, com a m\u00ednim, per als pacients que ara estan en la lluita, i per als seus familiars. Tot i que el temps va en contra, i l&#8217;\u00e0nsia de guariment, com sabem els que hem passat per aqu\u00ed, \u00e9s enorme.<\/p>\n<p>Des d&#8217;una perspectiva m\u00e8dica, el treball s&#8217;inscriu en la llarga hist\u00f2ria de l&#8217;intent de \u201cdrogabilitzar\u201d <strong>KRAS<\/strong>, un dels oncogens m\u00e9s infames de la biologia del c\u00e0ncer. Mutat aproximadament en el 90% dels tumors pancre\u00e0tics, KRAS ha estat durant d\u00e8cades considerat una diana gaireb\u00e9 intractable. Els inhibidors recents han demostrat una certa efic\u00e0cia, per\u00f2 el tumor desenvolupa resist\u00e8ncia en q\u00fcesti\u00f3 de mesos. L&#8217;estudi de l&#8217;equip de Barbacid parteix d&#8217;una hip\u00f2tesi sist\u00e8mica: <strong>la resist\u00e8ncia no se supera bloquejant un \u00fanic node molecular sin\u00f3 atacant simult\u00e0niament diversos punts cr\u00edtics de la xarxa de senyalitzaci\u00f3 tumoral<\/strong>. Reconec que, en ser un ignorant del tema, em va encantar filos\u00f2ficament la descripci\u00f3 que en va fer el mateix Barbacid, ja que uneix tant la perspectiva sist\u00e8mica de <strong>Mario Bunge<\/strong>, com una idea important en sistemes complexos: <strong>la rellev\u00e0ncia dels nodes de les xarxes complexes<\/strong>.<\/p>\n<p>Fixeu-vos que parlo de l&#8217;equip de Barbacid, tal i com ell fa sempre, un equip format majorit\u00e0riament per dones. Que ell en sigui el cap visible, per la seva experi\u00e8ncia i lideratge investigador des de fa anys, i que sigui home, no hi t\u00e9 res a veure, al meu entendre, amb certs debats de g\u00e8nere que estan proliferant. Si hi ha alguna cosa a dir que la diguin elles, les investigadores del CNIO. Som experts en buscar defectes i en no donar suport als nostres a nivell internacional. Recordeu el cas de la marginaci\u00f3 de <a href=\"https:\/\/en.wikipedia.org\/wiki\/Francisco_Mojica\">Francisco Mojica, descobridor de CRISPR<\/a>, que crec que hauria merescut el premi Nobel en el seu moment. I ara, si els assajos cl\u00ednics en humans funcionessin m\u00ednimament, penso que Mariano Barbacid tamb\u00e9 seria digne d&#8217;aquest guard\u00f3, potser conjuntament amb altres col\u00b7legues que han desenvolupat aquest tipus de ter\u00e0pies, i no nom\u00e9s per aquest article concret, sin\u00f3 per la seva dilatada traject\u00f2ria. I \u00e9s que aix\u00f2 no \u00e9s flor d&#8217;un dia, sin\u00f3 feina de molts anys. I, com passa a la ci\u00e8ncia moderna, des de fa d\u00e8cades els grans aven\u00e7os no s\u00f3n fruit de llops solitaris. Els equips s\u00f3n extensos i el Nobel se sol atorgar nom\u00e9s poques persones, moltes vegades -sobretot en f\u00edsica- com a representants de grans institucions, com el CERN, ATLAS, COBE, etc. <strong>El reconeixement p\u00fablic a Barbacid \u00e9s un reconeixement al CNIO<\/strong> i al seu equip. O aix\u00ed ho hauria de percebre qualsevol que entengui una mica de ci\u00e8ncia.<\/p>\n<p>Tornant al seu treball, l&#8217;enfocament experimental va consistir en una ter\u00e0pia triple amb <strong>tres f\u00e0rmacs la combinaci\u00f3 dels quals va produir regressi\u00f3 completa i duradora del tumor en ratolins<\/strong>, sense recaigudes durant m\u00e9s de 200 dies, un resultat excepcional en oncologia experimental. Com els deia, l&#8217;article aporta a m\u00e9s a m\u00e9s un argument te\u00f2ric interessant: l&#8217;ablaci\u00f3 gen\u00e8tica simult\u00e0nia de tres nodes del sistema \u00e9s suficient per provocar la regressi\u00f3 permanent del tumor, cosa que justifica racionalment la ter\u00e0pia farmacol\u00f2gica combinada. Des de la biologia de sistemes, l&#8217;estudi il\u00b7lustra com els tumors exploten redund\u00e0ncies a la xarxa de senyalitzaci\u00f3, i com una intervenci\u00f3 multipunt pot fer col\u00b7lapsar aquesta xarxa, evitant rutes d&#8217;escapament adaptatiu.<\/p>\n<p><a href=\"https:\/\/www.cnio.es\/en\/news\/the-group-led-by-barbacid-at-cnio-completely-eliminates-pancreatic-tumours-in-mice-with-no-resistance-developing\/\">La not\u00edcia divulgativa del CNIO<\/a> emfatitza que (en ratolins, cal insistir-hi) els tumors van desapar\u00e8ixer sense toxicitats significatives, i que el tractament va prevenir l&#8217;aparici\u00f3 de resist\u00e8ncies, un dels principals problemes de les ter\u00e0pies dirigides actuals. Tanmateix, els mateixos autors subratllen que encara no estan en condicions d&#8217;iniciar assajos cl\u00ednics, i que l&#8217;optimitzaci\u00f3 translacional ser\u00e0 complexa i lenta. I aqu\u00ed \u00e9s crucial introduir una advert\u00e8ncia epistemol\u00f2gica: <strong>el salt del model mur\u00ed a la cl\u00ednica humana \u00e9s incert<\/strong>. Els ratolins toleren toxicitats que en humans resultarien inacceptables, i els microambients tumorals, la farmacocin\u00e8tica i l&#8217;heterogene\u00eftat gen\u00e8tica difereixen substancialment entre esp\u00e8cies. Algun dels f\u00e0rmacs implicats, diuen els experts, presenta efectes adversos coneguts en humans, i el mateix estudi alerta que l&#8217;eliminaci\u00f3 total de KRAS en ratolins adults t\u00e9 possibles efectes col\u00b7laterals sist\u00e8mics.<\/p>\n<p>Des d&#8217;una perspectiva filos\u00f2fica de la biomedicina, el treball segueix un canvi de paradigma: no es tracta de trobar la \u201cbala m\u00e0gica\u201d, sin\u00f3 de <strong>dissenyar c\u00f2ctels racionals que col\u00b7lapsin xarxes de senyalitzaci\u00f3 complexes<\/strong>. Aquest enfocament recorda les ter\u00e0pies combinades que es fan servir per exemple contra el VIH, o altres quimioter\u00e0pies multif\u00e0rmac, per\u00f2 amb una fonamentaci\u00f3 molecular molt precisa.<\/p>\n<p>En conclusi\u00f3, l&#8217;estudi de l&#8217;equip de Barbacid constitueix un resultat precl\u00ednic en models murinos, amb <strong>un tros per rec\u00f3rrer abans de qualsevol aplicaci\u00f3 cl\u00ednic<\/strong>a. La hist\u00f2ria de l&#8217;oncologia est\u00e0 repleta de ter\u00e0pies en ratolins que van fracassar en humans, per la qual cosa cal ser cautelosos: s\u00ed que \u00e9s, no obstant aix\u00f2, un pas significatiu conceptualment cap a ter\u00e0pies combinades de precisi\u00f3. Tamb\u00e9, per descomptat, crea una cosa fonamental als passadissos dels hospitals: <strong>esperan\u00e7a<\/strong>. Gr\u00e0cies, de cor, professor Barbacid, a vost\u00e8 i a tot el seu equip, per aquest esfor\u00e7 tit\u00e0nic en una cosa tan important per a molta gent.<\/p>\n<hr \/>\n<h6><strong>Refer\u00e8ncies:<\/strong><\/h6>\n<p>Liaki, V. et al. (2025). <em>A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance<\/em>,\u00a0<em>Proc. Natl. Acad. Sci.<\/em>\u00a0122 (49) e2523039122,\u00a0<a href=\"https:\/\/doi.org\/10.1073\/pnas.2523039122\">https:\/\/doi.org\/10.1073\/pnas.2523039122<\/a>\u00a0 (2025).<\/p>\n<hr \/>\n<p>Font:\u00a0<strong>educational EVIDENCE<\/strong><\/p>\n<p>Drets:\u00a0<strong>Creative Commons<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>El 2008 la meva mare va morir de c\u00e0ncer de p\u00e0ncrees. Se la va endur en pocs mesos. Encara que, per descomptat, la bestiola feia m\u00e9s temps que estava dins, sense avisar. El c\u00e0ncer de p\u00e0ncrees, en particular l&#8217;adenocarcinoma ductal pancre\u00e0tic (PDAC), continua sent des de llavors una de les neopl\u00e0sies m\u00e9s letals. La seva resist\u00e8ncia a les ter\u00e0pies convencionals i el diagn\u00f2stic tard\u00e0 han convertit aquesta malaltia en un paradigma del frac\u00e0s terap\u00e8utic en oncologia.<\/p>\n","protected":false},"author":4,"featured_media":33163,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[219],"tags":[4049,4053,4051,4050,4052,4048],"class_list":["post-33213","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencia-ca","tag-cancer-de-pancrees","tag-cnio","tag-kras","tag-mariano-barbacid","tag-pdac","tag-xarxes-de-senyalitzacio-complexes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gr\u00e0cies, Barbacid - Educational Evidence<\/title>\n<meta name=\"description\" content=\"El 2008 la meva mare va morir de c\u00e0ncer de p\u00e0ncrees. 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